The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated.” Therefore, use with caution in dogs with a history of seizures or neurologic disorders. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. This class has been associated with neurologic adverse reactions, including tremors, ataxia, and seizures. The package insert for NexGard says: “Afoxolaner is a member of the isoxazoline class. In 2018, due to consistent reports of serious adverse effects, all companies that manufacture flea and tick prevention products based on isoxazoline had to change their labels and include a clear warning about potentially irreversible side effects to the nervous system. The damage is done.” - Melanie and her dog Ely What Does NexGard's Package Insert Say? It's fine until it's not, and you won't know till it's too late and there is no antidote to reverse it. From what I know from others, it's a bit like Russian roulette. So, why my dog? Well, after reading the dangers and understanding how Nexgard works killing fleas, it made sense how it could have the same effect on my dog. In fact, I know lots of dogs and owners in those lines all across the country. So, many dogs were bred throughout his lines with no epilepsy. His sire is a silver grand champion, dam grand champion, and numerous others in his lines are also champions. “I talked with his breeder, and no others in his lines have had epilepsy and none since. Her Sheltie, previously a healthy agility dog, started seizing after NexGard. One dog owner I spoke to compared it to Russian roulette. NexGard's cross-species neurotoxicity creates a dangerous gamble for dog owners who opt to give their dogs this product. Once this happens, there is often no way back. There is a reason why so many dogs experience seizures, ataxia, and tremors after taking NexGard - the pesticide compromises the dog's central nervous system. Isoxazolines are neurotoxic to more than just insects they also affect mammals. And yet, almost a decade of reported adverse effects by dog owners and veterinary professionals shows a different truth. NexGard's package insert emphasizes “selective toxicity” of isoxazolines, stating they are only toxic to insects and acarine, not mammals. Isoxazolines are neurotoxic they work by targeting the insect's central nervous system, which quickly leads to death. Other FDA-approved products in the isoxazoline group that target ticks and fleas in pets are Bravecto and Bravecto Plus (tablets and topical solutions for cats and dogs), Credelio (tablets for cats and dogs), Simparica and Simparica Trio (tablets for dogs), and Revolution Plus (topical solutions for cats).Ī Pesticide That Targets the Central Nervous System The active ingredient in NexGard is called afoxolaner - a pesticide from a class of chemicals called isoxazolines. If you are hearing about this product for the first time or swear by it as your go-to flea and tick prevention, this article sheds light on how NexGard can harm your dog and why you should feel comfortable saying no if your veterinarian suggests it. Most dog owners only become aware of NexGard's dark side after it's already too late for their dogs. Ever since it got approved for veterinary use, it has been catching heat from dog owners who have seen horrific adverse effects in their dogs - including death. One would assume that a product put on the market with the intent to protect dogs would never harm them, but NexGard doesn't quite fit that profile. NexGard is marketed as a monthly flea and tick prevention that comes in the form of a convenient chewable treat.
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